Tiono AB, Ouédraogo A, Diarra A, Coulibaly S, Soulama I, Konaté AT, et al. Correlating quantitative real-time PCR to rapid diagnostic test and RNA transcript expression in isolated gametocytemia and asexual parasitemia of Plasmodium falciparum malaria. A survival analysis between RDT, qPCR and microscopic diagnostics for clinically relevant asexual parasitemia in post-treatment specimens, highlighting that microscopy remains the only reliable method that can ascertain between asexual parasitemia and prolonged clearance of antigen. Survival analysis of diagnostic assays in Plasmodium falciparum malaria. Phuong M, Lau R, Ralevski F, Boggild AK.Epidemiology and clinical features of imported malaria in East London. An analysis of 323 PCR-confirmed malaria patients that showed improvements in performance when LDH and HRP2-based RDTs were used in combination.įrancis B, Gonzalo X, Duggineni S, Thomas JM, NicFhogartaigh C, Babiker ZO. Combining parasite lactate dehydrogenase-based and histidine-rich protein 2-based rapid tests to improve specificity for diagnosis of malaria due to Plasmodium knowlesi and other Plasmodium species in Sabah, Malaysia. Grigg MJ, William T, Barber BE, Parameswaran U, Bird E, Piera K, et al.A comprehensive systematic review outlining the efficacy of malaria RDTs specifically for non- falciparum / P. Rapid diagnostic tests for diagnosing uncomplicated non- falciparum or Plasmodium vivax malaria in endemic countries. Abba K, Kirkham AJ, Olliaro PL, Deeks JJ, Donegan S, Garner P, et al.Recommended selection criteria for procurement of malaria rapid diagnostic tests. Five things to know about: rapid diagnostic tests for imported malaria. Atlanta: Center for Disease Control and Prevention 2015. 2016 15(1):555.Ĭenter for Disease Control and Prevention. Low prevalence of laboratory-confirmed malaria in clinically diagnosed adult women from the Wakiso district of Uganda. Yegorov S, Galiwango RM, Ssemaganda A, Muwanga M, Wesonga I, Miiro G, et al. Malaria rapid diagnostic test performance: summary results of WHO product testing of malaria RDTs: round 1-7 (2008–2016). Malaria rapid diagnostic tests in travel medicine. Malaria rapid diagnostic tests in endemic settings. Ottawa: Public Health Agency of Canada 2014. Canadian recommendations for the prevention and treatment of malaria. Ĭommittee to Advise on Tropical Medicine and Travel (CATMAT). Papers of particular interest, published recently, have been highlighted as: knowlesi, and Plasmodium malariae, and surmount the issue of pfhrp2 gene deletions, while maintaining comparable performance to both PCR and expert microscopy reference standards. Future work should facilitate the development of improved RDT platforms for Plasmodium ovale, P. The past 5 years have been characterized by increasing demand for malaria RDTs, translating into meaningful improvements in performance and novel biotechnological innovation. Trends have emerged in recent malaria RDT literature: (1) improvements in the sensitivity and specificity of RDTs for Plasmodium falciparum diagnosis, making them comparable to expert microscopic examination (2) reduced false-positive and false-negative reactions with novel antibody development (3) improved sensitivity and specificity capabilities of Plasmodium vivax-specific RDTs (4) developing RDTs for co-endemic mixed infection differentiation (5) significant improvements of RDTs for Plasmodium knowlesi (6) a global push towards assessing and confronting the growing concerns of widespread pfhrp2 gene deletions and (7) original innovation in loop-mediated isothermal amplification (LAMP) biotechnological RDT-like platforms that demonstrate promising performance characteristics for P. Substantial developments in diagnostic sensitivity and specificity, improvements in non-falciparum RDTs, and novel biotechnological innovations are gradually aligning the performance of RDTs with reference-level diagnostics including PCR and expert microscopy gold standards. Modern advances in malaria rapid diagnostic test (RDT) technology have increased demand for low-cost, easy-to-use assays in areas endemic for malaria.
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